Hierarchical binding of copperII to N-truncated Aβ4–16 peptide

Abstract

N-Truncated Aβ_4-42 displays a high binding affinity with Cu^II. A mechanistic scheme of the interactions between Aβ_4-42 and Cu^II has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aβ_4-42 during neurotransmission.