Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus

Abstract

S-ibuprofen clearance shows important maturation, especially with PNA, resulting in an up to 3-fold increase in CL_S during a 3-day treatment regimen. This rapid increase in clearance needs to be incorporated in dosing guidelines by adjusting the dose for every day after birth to achieve equal ibuprofen exposure.