Biomaterials Science · 2020 · 17 citations · 18 references
Natural SciencesMaterials EngineeringMaterials ScienceBiomaterialsNanomaterialsPolymer ChemistryBiodegradationNanoparticle CharacterizationNanoparticle StabilityPolymer DegradationPolymeric NanomaterialsPolymeric NanoparticlesBiodegradable Polymeric NanoparticlesOxidative Degradation StudiesPolycaprolactonePolycaprolactone DegradationPolymer Degradation KineticsPolymer Degradation MechanismsPolymeric Nanoparticle Stability
We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.
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Caroline de Gracia Lux, Shivanjali Joshi-Barr, Trung Van Nguyen et al. · Journal of the American Chemical Society · 2012 · 594 citations
Natural Sciences, Bioengineering, Biomedical Engineering +17
Oxidation-Accelerated Hydrolysis of the Ortho Ester-Containing Acid-Labile Polymers
Chengcheng Song, Ran Ji, Fu‐Sheng Du et al. · ACS Macro Letters · 2013 · 112 citations
Fast Degradable Polycaprolactone for Drug Delivery
Seo Hee Chang, Hyun Jung Lee, Sohee Park et al. · Biomacromolecules · 2018 · 102 citations