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Spironolactone Metabolite Concentrations in Decompensated Heart Failure: Insights from the ATHENA-HF Trial

DOIFull Paper Access

28

Citations

22

References

2020

Year

Simon de Denus, Grégoire Leclair, Marie‐Pierre Dubé, Isabelle St‐Jean, Yassamin Feroz Zada, Essaïd Oussaïd, Martin Jutras, Michael M. Givertz, Robert J. Mentz, W.H. Wilson Tang,
European Journal of Heart Failure

Abstract

Lower-than-anticipated concentrations of spironolactone active metabolites were observed for at least 48 h in the high-dose spironolactone group and may have contributed to the absence of pharmacological effects of spironolactone in the ATHENA-HF trial.

References

YearCitations

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