Transcriptome analysis of the response provided by Lasiopodomys mandarinus to severe hypoxia includes enhancing DNA repair and damage prevention

Abstract

<i>L. mandarinus</i> has evolved hypoxia adaptation by enhancing DNA repair, damage prevention, and augmenting sensing, whereas <i>L. brandtii</i> showed a higher risk of tumorigenesis and promoted innate immunity toward severe hypoxia. These results reveal the hypoxic mechanisms of <i>L. mandarinus</i> to severe hypoxia, which may provide research clues for hypoxic diseases.