Concepedia

N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex.

Jing Sun, Dawei Meng, Tao Yu, Feng Li, Guirong Zhang, Xin Tian, Nannan Zhao, Guimin Li, Lu Li, Hongyue Wang,

PubMed · 2020 · 16 citations · 22 references

Open access

Concepts

MedicineCell BiologyOncologyEpigeneticsMolecular Cell BiologyMolecular OncologyCancer Cell SignalingCancer EpigeneticsEpigenetic Regulation In CancerMetastatic Signaling PathwaysOncogenic Signaling PathwaysAlternative Splicing RegulationE-cadherin FunctionEpithelial Tissue HomeostasisGene Promoter RegulationH3k27 TrimethylationHistone AcetylationHistone-lysine AcetylationLung Adenocarcinoma

Abstract

and provide novel insights into CPEΔN-associated lung cancer metastasis.

References

22

Global cancer statistics, 2012

Lindsey A. Torre, Freddie Bray, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2015 · 27.4K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Cancer statistics in China, 2015

Wanqing Chen, Rongshou Zheng, Peter D. Baade et al. · CA A Cancer Journal for Clinicians · 2016 · 18K citations · Full text

Medicine, Oncology, Population Health Sciences +17

Carboxypeptidase E Is a Regulated Secretory Pathway Sorting Receptor: Genetic Obliteration Leads to Endocrine Disorders in Cpefat Mice

David R. Cool, Emmanuel Normant, Fusheng Shen et al. · Cell · 1997 · 454 citations

Life Sciences, Endocrinology, Molecular Biology +11

Polycomb Complex 2 Is Required for <i>E-cadherin</i> Repression by the Snail1 Transcription Factor

Nicolás Herranz, Diego Pasini, Víctor M. Diaz et al. · Molecular and Cellular Biology · 2008 · 421 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Structure of the complete elongation complex of RNA polymerase II with basal factors

Haruhiko Ehara, Takeshi Yokoyama, Hideki Shigematsu et al. · Science · 2017 · 219 citations

Life Sciences, Genetics, Molecular Biology +17