20:T4b4,All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy is imperative. Here, we develop a drug self-delivery system for cancer therapy, in which anticancer drugs can be delivered by themselves without any carriers. To demonstrate this unique approach, an amphiphilic drug-drug conjugate (ADDC) has been synthesized from the hydrophilic anticancer drug irinotecan (Ir) and the hydrophobic anticancer drug chlorambucil (Cb) via a hydrolyzable ester linkage. The amphiphilic Ir-Cb conjugate self-assembles into nanoparticles in water and exhibits longer blood retention half-life compared with the free drugs, which facilitates the accumulation of drugs in tumor tissues and promotes their cellular uptake. A benefit of the nanoscale characteristics of the Ir-Cb ADDC nanoparticles is that the multidrug resistance (MDR) of tumor cells can be overcome efficiently. After cellular internalization, the ester bond between hydrophilic and hydrophobic drugs undergoes hydrolysis to release free Ir and Cb, resulting in an excellent anticancer activity in vitro and in vivo.21:T468,Hollow structures with an efficient light harvesting and tunable interior component offer great advantages for constructing a Z-scheme system. Controlled design of hollow cobalt sulfide (Co₉ S₈ ) cubes embedded with cadmium sulfide quantum dots (QDs) is described, using hollow Co(OH)₂ as the template and a one-pot hydrothermal strategy. The hollow CdS/Co₉ S₈ cubes utilize multiple reflections of light in the cubic structure to achieve enhanced photocatalytic activity. Importantly, the photoexcited charge carriers can be effectively separated by the construction of a redox-mediator-free Z-scheme system. The hydrogen evolution rate over hollow CdS/Co₉ S₈ is 134 and 9.1 times higher than that of pure hollow Co₉ S₈ and CdS QDs under simulated solar light irradiation, respectively. Moreover, this is the first report describing construction of a hollow Co₉ S₈ based Z-scheme system for photocatalytic water splitting, which gives full play to the advantages of light-harvesting and charges separation.

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