Chemical Communications · 2020 · 70 citations · 29 references
EngineeringBioengineeringBiomedical EngineeringBiosensorsMolecular DiagnosticsSensorsAptamer-based BiosensorsBiomarkers Of NeurodegenerationDna BiosensorsMolecular SensorsNucleic Acid BiosensorsParkinson DiseaseAptamer BiosensorsAptamer RecognitionAptamer-based BiosensingAptamer-based DetectionAptamer-based SensorsDna Aptamer-based BiosensorsEarly DiagnosisProtein Detection
A liquid crystal biosensor based on DNA aptamer for sensitive detection of Parkinson's Disease (PD) related alpha-synuclein was developed. This LC biosensor is constructed using a simple and label free method, and it not only enables early PD diagnosis, but also provides a general platform for detection based on DNA aptamer.
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In vivo demonstration that α-synuclein oligomers are toxic
Beate Winner, Roberto Jappelli, Samir K. Maji et al. · Proceedings of the National Academy of Sciences · 2011 · 1.5K citations · Full text
Biomolecular Interactions at Phospholipid-Decorated Surfaces of Liquid Crystals
Jeffrey M. Brake, Maren K. Daschner, Yan‐Yeung Luk et al. · Science · 2003 · 628 citations
Optical Amplification of Ligand-Receptor Binding Using Liquid Crystals
Vinay Gupta, Justin J. Skaife, T. Dubrovsky et al. · Science · 1998 · 471 citations
Pharmacy, Biochemistry, Biophysics +16