PubMed · 2020 · 13 citations · 0 references
MedicineMolecular BiologyOncologyMetastasisMolecular OncologySignal TransductionCancer Cell SignalingCancer ProgressionEsophageal CancerMalignant NeoplasmsSignal Transduction In CancerSquamous Cell CarcinomaCancer Signaling PathwaysMembrane Receptor ActivationMembrane Receptor SignalingPlasminogen ActivatorsWestern Blotting
knockdown significantly inhibited xenograft growth and lung metastasis of ESCC cells. Molecular analysis demonstrated that PAI-1 activated AKT and ERK signaling pathways. Co-immunoprecipitation (Co-IP) assays identified that PAI-1 may interact with the membrane receptor LDL receptor related protein 1 (LRP1). These results indicated that overexpression of PAI-1, through interacting with LRP1, might enhance invasion and migration of ESCC cells as well as promote ESCC progression.