Reinforced Topological Nanoassemblies: 2D Hexagon-Fused Wheel to 3D Prismatic Metallo-Lamellar Structure with Molecular Weight of 119 K Daltons

Abstract

By a precise metallo-ligand design, the advanced coordination-driven self-assembly could succeed in the preparation of giant molecular weight of the metallo-architectures. However, the synthesis of a single discrete high-molecular-weight (>100 K Da) structure has not been demonstrated due to the insurmountable synthetic challenge. Herein, we present a two-dimensional wheel structure (<b>W1</b>) and a gigantic three-dimensional dodecagonal prism-like architecture (<b>P1</b>), which were generated by multicomponent self-assembly of two similar metallo-organic ligands and a core ligand with metal ions, respectively. The giant 2D-suprastructure <b>W1</b> with six hexagonal metallacycles that fused to the central spoke wheel was first achieved in nearly quantitative yield, and then, directed by introducing a meta-substituted coordination site into the key ligand, the supercharged (36 Ru²⁺ and 48 Cd²⁺ ions) double-decker prismatic structure <b>P1</b> with two wheel structure <b>W1</b>s serve as the surfaces and 12 <Tpy-Cd²⁺-Tpy> connectivities serve as the edges, where a molecular weight up to 119 498.18 Da was accomplished. The expected molecular composition and size morphology was unequivocally characterized by nuclear magnetic resonance, mass spectrometry, and transmission electron microscopy investigations. The introduction of a wheel structure is able to add considerable stability and complexity to the final architecture. These well-defined scaffolds are expected to play an important role in the functional materials field, such as molecular encapsulation and medicine sustained release.