A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca²⁺ release capacity in the skeletal muscle of aged mice

Abstract

The aim of this study was to examine the effect of high-fat diet (HFD)-induced obesity on contractile function and Ca 2+ release capacity in aged skeletal muscle. Not only were the force production and peak Ca 2+ levels decreased by aging and HFD feeding, respectively, but also, these interventions had an additive effect in aged HFD-fed mice. These data suggest that the impairment in the contractile force in aged muscle is aggravated by a HFD, which may be due to synergistic dysfunction in intracellular Ca 2+ release.