Dual Catalytic Platform for Enabling sp ³ α C–H Arylation and Alkylation of Benzamides

Abstract

A dual catalytic sp3 α C–H arylation and alkylation of benzamides with organic halides is described. This protocol exhibits an exquisite site selectivity, chemoselectivity, and enantioselectivity pattern, offering a complementary reactivity mode to existing sp3 arylation or alkylations via transition metal catalysis or photoredox events.