Cold‐inducible RNA‐binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps

Abstract

The upregulated production and release of CIRP from nasal epithelial cells and macrophages may contribute to the edema formation in both eosinophilic and noneosinophilic CRSwNP by inducing MMP and VEGF-A production from epithelial cells and macrophages.