Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from <i>Uvaria grandiflora</i>

Abstract

Chromatographic purification of the DCM sub-extract of <i>Uvaria grandiflora</i> led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (<b>1</b>), together with five known compounds. Among the compounds isolated, zeylenone (<b>3</b>) showed moderate antitubercular activity against <i>Mycobacterium tuberculosis</i> H₃₇Rv with MIC₉₀ value of 51.2 μM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC₅₀ values of 2.3 and 18.3 μM, respectively.