Efficient Tailoring of Platinum Nanoparticles Supported on Multiwalled Carbon Nanotubes for Cancer Therapy

Abstract

<b>Aim:</b> Therapeutically targeting cancer stem cells (CSCs), which play a role in tumor initiation and relapse, remains challenging. <b>Materials & methods:</b> Novel-formulated platinum nanoparticles (Pt-NPs) supported on polybenzimidazole (PBI)-functionalized polymers and multiwalled carbon nanotubes (MWCNT) were prepared and their effect on CSCs was evaluated. <b>Results:</b> Pt-NPs showed homogenous distribution on the surface of MWCNT/PBI composites, with very narrow particle size. MWCNT/PBI/Pt-NPs resulted in a dramatic decrease in the proliferation rate of CSCs but not bone marrow mesenchymal stem cells (BM-MSCs). Quantitative gene expression analysis revealed that MWCNT/PBI/Pt had a significant inhibitory effect on the epithelial-mesenchymal transition and cell cycle markers of CSCs. <b>Conclusion:</b> MWCNT/PBI/Pt exhibited a specific cytotoxic effect on breast CSCs but not on adult stem cells.