Veterinary MedicineImmunologyPathologyInflammationInnate ImmunitySignal TransductionFibrosisInterstitial Lung DiseasePulmonary InflammationPulmonary PathologyRespiratory PathologyFibrotic Interstitial Lung DiseaseInterstitital Lung DiseaseLung FibrosisNlrp3 InflammasomeNlrp3-associated DiseasePulmonary Fibrosis ProgressionPulmonary PathogenesisSilicosis
NLRP3 and its downstream factors Caspase-1, IL-1β, IL-18 and TGF-β1 are highly expressed in the lung tissue of rats with silicosis and pulmonary fibrosis, suggesting that the NLRP3/IL-1β/TGF-β(1) signal axis may be associated with silicosis. Pulmonary fibrosis has a close relationship and plays a role in the formation of silicosis.