Concepedia

Development of an efficient and sustainable synthesis of 2-(3-methyl-1 <i>H</i> -1,2,4-triazol-1-yl) acetic acid under continuous-flow conditions

Simone Tortoioli, Astrid Friedli, Alice Prud’homme, Sylvia Richard‐Bildstein, Philipp Köhler, Stefan Abele, Gianvito Vilé

Green Chemistry · 2020 · 17 citations · 20 references

DOIFull text

Open access

Concepts

Abstract

A novel, metal-free process for the challenging synthesis of 1,2,4-triazoles is reported, which features an efficient construction of the triazole ring under flow conditions.

References

20

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

Andrea Adamo, Rachel L. Beingessner, Mohsen Behnam et al. · Science · 2016 · 937 citations

, , +16

Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

Simon Lawton, Gerry Steele, P. Shering et al. · Organic Process Research & Development · 2009 · 311 citations

, , +9

Heterocyclic Chemistry

Siegfried R. Waldvogel · Synthesis · 2011 · 270 citations · Full text

Flow approaches towards sustainability

Luigi Vaccaro, Daniela Lanari, Assunta Marrocchi et al. · Green Chemistry · 2014 · 229 citations

, , +16

Efficient Transamidation of Primary Carboxamides by in Situ Activation with <i>N</i>,<i>N</i>-Dialkylformamide Dimethyl Acetals

Thomas A. Dineen, Matthew Zajac, Andrew G. Myers · Journal of the American Chemical Society · 2006 · 148 citations

, , +11