PTH/PTHrP Receptor Signaling Restricts Arterial Fibrosis in Diabetic LDLR ^−/− Mice by Inhibiting Myocardin-Related Transcription Factor Relays

Abstract

PTH1R signaling restricts collagen production in the VSM lineage, in part, via Mkl-1 regulatory circuits that control collagen gene transcription. Strategies that maintain homeostatic VSM PTH1R signaling, as reflected in extracellular vesicle biomarkers of VSM PTH1R/Mkl-1 action, may help mitigate arteriosclerosis and vascular fibrosis.