JAMA · 2020 · 2.2K citations · 7 references
MedicineInfectious Disease ControlInfectious DiseasesCritical Care MedicineOutbreak InvestigationCritical CareDisease ControlOutbreak ControlOutbreak ManagementPandemic ResponseHospital Outbreak ManagementIntensive Care UtilizationResource Allocation During Outbreaks
On February 20, 2020, a patient in his 30s admitted to the intensive care unit (ICU) in Codogno Hospital (Lodi, Lombardy, Italy) tested positive for a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). He had a history of atypical pneumonia that was not responding to treatment, but he was not considered at risk for COVID-19 infection. he positive result was immediately reported to the Lombardy health care system and governmental offices. During the next 24 hours, the number of reported positive cases increased to 36. This situation was considered a serious development for several reasons: the patient ("patient 1") was healthy and young; in less than 24 hours, 36 additional cases were identified, without links to patient 1 or previously identified positive cases already in the country; it was not possible to identify with certainty the source of transmission to patient 1 at the time; and, because patient 1 was in the ICU and there were already 36 cases by day 2, chances were that a cluster of unknown magnitude was present and additional spread was likely.
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Clinical Characteristics of Coronavirus Disease 2019 in China
Wei‐jie Guan, Zhengyi Ni, Yu Hu et al. · New England Journal of Medicine · 2020 · 31.2K citations · Full text
Veterinary Medicine, Infectious Diseases, Internal Medicine +10
Presumed Asymptomatic Carrier Transmission of COVID-19
Yan Bai, Tao Wei, Fei Tian et al. · JAMA · 2020 · 4.9K citations · Full text
Veterinary Medicine, Infectious Diseases, Infectious Disease Epidemiology +10