Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via <i>O</i> -linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

Abstract

Diabetic hyperglycemia induces acute cardiac myocyte ROS production by NOX2 that requires <i>O</i>-GlcNAcylation of CaMKIIδ at S280. This novel ROS induction may exacerbate pathological consequences of diabetic hyperglycemia.