Trifluoromethylation/Difluoromethylation‐Initiated Radical Cyclization of <i>o</i>‐Alkenyl Aromatic Isocyanides for Direct Construction of 4‐Cyano‐2‐Trifluoromethyl/Difluoromethyl‐Containing Quinolines

Abstract

Abstract In this study, a radical‐triggered cyclization of o ‐alkenyl aromatic isocyanides prepared from accessible starting materials is developed. The reaction provides a general and efficient method for the synthesis of 4‐CN‐2‐CF 3 /CF 2 H‐containing quinolines under copper or visible‐light photoredox catalysis in a one‐pot synthetic procedure. This protocol demonstrates good to high yields, broad substrate scope, and good functional group tolerance. magnified image