medRxiv · 2020 · 29 citations · 3 references
Life SciencesInfectious DiseasesMicrobiologyMedical MicrobiologyMolecular VirologyVirologyInfectious Disease DetectionInfectious Disease SurveillanceViral DiagnosticsViral EpidemiologyViral InfectionsCoronavirus Infection ControlFecal-oral TransmissionSars-cov-2 InfectionStool Sample CollectionTropical Infectious Diseases
Abstract The rapid spread of coronavirus disease 2019 (COVID-19) raises concern about a global pandemic. Knowledge about the duration of viral shedding remains important for patient management and infection control. We report the duration of viral detection in throat and rectum of a COVID-19 patient treated at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam. Despite clinical recovery, SARS-CoV-2 RNA remained detectable by real time RT-PCR in throat and rectal swabs until day 11 and 18 of hospitalization, respectively. Because live SARS-CoV-2 has been successfully isolated from a stool sample from a COVID-19 patient in China, the results demonstrate that COVID-19 patients may remain infectious for long periods, and fecal-oral transmission may be possible. Therefore, our finding has important implications for infection control.
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Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
Victor M. Corman, Olfert Landt, Marco Kaiser et al. · Eurosurveillance · 2020 · 8.2K citations · Full text
First Case of 2019 Novel Coronavirus in the United States
Michelle Holshue, Chas DeBolt, Scott Lindquist et al. · New England Journal of Medicine · 2020 · 6.4K citations · Full text