Concepedia

Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice

Anna Isaacs‐Ten, Marta Echeandia, Mar Moreno‐Gonzalez, Arlaine Brion, Andrew Goldson, Mark Philo, Angela Patterson, Aimée Parker, Mikel Galduroz, David Baker,

Hepatology · 2020 · 76 citations · 28 references

DOIFull text

Open access

Abstract

We demonstrate that the intestinal microbiome contributes to cholestasis-mediated cell death and inflammation through mechanisms involving activation of the inflammasome in macrophages.

References

28

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

Sama I. Sayin, Annika Wahlström, Jenny Felin et al. · Cell Metabolism · 2013 · 2.2K citations · Full text

, , +9

Liver cirrhosis

The Lancet · 2008 · 1.9K citations · Full text

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

Rebecca C. Coll, James R. Hill, Christopher J. Day et al. · Nature Chemical Biology · 2019 · 931 citations · Full text

, , +11

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

Shuhong Guo, Rana Al–Sadi, Hamid M. Said et al. · American Journal Of Pathology · 2012 · 674 citations · Full text

Microbial shifts in the aging mouse gut

Morgan G. I. Langille, Conor J. Meehan, Jeremy E. Koenig et al. · Microbiome · 2014 · 431 citations · Full text