Chiral phosphoric acid catalyzed asymmetric arylation of indoles<i>via</i>nucleophilic aromatic substitution: mechanisms and origin of enantioselectivity

Abstract

Asymmetric arylation of indoles<italic>via</italic>nucleophilic aromatic substitution can be effectively achieved using chiral phosphoric acid as catalyst, where the mechanisms and origin of enantioselectivity were explored theoretically.