A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging

Abstract

On the basis of the pyridazinone scaffold and photoinduced electron transfer (PET) mechanism, we designed a smart nitric oxide (NO) probe, <b>PYSNO</b>, with high sensitivity and selectivity. <b>PYSNO</b> exhibited a rapid response to both exogenous and endogenous NO. This probe can also be used in tracking and investigating NO generation in animal tissue. In the myocardial fibrosis model for mice, <b>PYSNO</b> exhibited a powerful imaging property in vivo as a result of unravelling the progressive relationship between the generation of myocardial NO and the occurrence of myocardial fibrosis.