Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes

Abstract

We found that activation of the LXR pathway with synthetic LXR agonists could elicit potent anti-HBV activity in PHHs, possibly through sustained suppression of cccDNA transcription. Our work highlights the therapeutic potential of targeting the LXR pathway for the treatment of chronic HBV infection.