Determination and Correlation of <scp>d</scp>-Ribose Solubility in Twelve Pure and Four Binary Solvent Systems

Abstract

Experimental solubility data of d-ribose in four binary (2-propanol + 1-hexane, ethanol + 1-hexane, methanol + dichloromethane, and ethanol + dichloromethane) and twelve pure (1-hexane, dichloromethane, ethyl acetate, acetonitrile, acetone, 2-methyl-1-propanol, 1-butanol, 2-propanol, 2-butanol, 1-propanol, ethanol, and methanol) solvent systems were measured at different temperatures under the atmospheric pressure by using the gravimetric method. The experimental results showed that the solubility of d-ribose increased with the increase of temperature and the content of positive solvent, and decreased with the increase of antisolvent composition. The dissolution behavior of d-ribose in pure solvents was mainly affected by the solvent types and solvent properties, and the solvent effect on d-ribose solubility was further examined by the KAT-LSER model. The solubility data were correlated by the modified Apelblat, Jouyban–Acree, and Apelblat–Jouyban–Acree models. The calculated values of the three thermodynamic models were in good agreement with the experimental data.