Research of the potential biomarkers in vaginal microbiome for persistent high-risk human papillomavirus infection

Abstract

A predominance of <i>Prevotella bivia, Enterococcus durans</i> and <i>Porphyromonas uenonis</i> with a concomitant paucity of <i>Lactobacillus iners</i> and <i>Prevotella disiens</i> may relate to HPV persistent infection. Furthermore, the relative abundance of <i>Prevotella bivia</i> being over 0.05554% with <i>Prevotella disiens</i> being under 0.02196% may be a good predictor for appearance CIN2+ for those diagnosed with the other 12 types of HR-HPV persistent infection but normal ThinPrep cytology test (TCT) testing. The exact molecular mechanism of the vaginal microbiome in the course of persistent HR-HPV infection and cervical neoplasia should be further explored. Future research should include intervention of vaginal microbiome composition to reverse the course of HR-HPV infection and the natural history of cervical neoplasia.