New nanostructure based on hydroxyapatite modified cellulose for bone substitute, synthesis, and characterization

Abstract

In the last decade calcium phosphate composites and other related biomaterials, were commercially used for bone substitution or allogrefts. In this study, a method was developed for purpose. In this composite hydroxyapatite (HAp) was placed in a cellulose structure by dissolving and precipitation technique. The produced biocompatible composites were extensively characterized by means of Fourier-transform infrared spectroscopy, thermogravimetric analysis, powder X-ray diffraction, dynamic light scattering, and scanning electron microscopy. The analysis results showed that, Hap successfully included in cellulose network without affecting its crystallinity, or the properties of either cellulose or HAp. The analysis also revealed a strong physical interaction between the composite components. Therefore, the composite appears to be a useful for the fabrication of bioactive film that can be used in the Bone Tissue Engineering field. Novelty of this work is the synthesis of nanocomposites based on hydroxyapatite and cellulose to get nanomaterials by a new method of synthesis in organic chemistry, which is called the double decomposition method. This method creates patterns between the organic matrix and inorganic. The second object is to replace classical materials with new nanomaterials for medical and orthopedic uses.