RNA‐Seq Analysis of Genetic and Transcriptome Network Effects of Dual‐Trait Selection for Ethanol Preference and Withdrawal Using SOT and NOT Genetic Models

Abstract

Marked effects of selection on gene expression were detected. The NOT line was characterized by higher expression of hub nodes associated with mitochondrial function. Genes more highly expressed in the SOT aligned with previous findings, for example, Colville and colleagues (Genes Brain Behav 16, 2017, 462) that both high EtOH preference and consumption are associated with effects on cell adhesion and glutamate synaptic plasticity.