T<sub>2</sub>-FLAIR Mismatch Sign Is Caused by Long T<sub>1</sub> and T<sub>2</sub> of <i>IDH</i>-mutant, 1p19q Non-codeleted Astrocytoma

Abstract

T₂-fluid-attenuated inversion recovery images (FLAIR) mismatch sign is now known to be a specific yet insensitive image feature for IDH-mutant, 1p19q non-codeleted astrocytoma. The current study revealed that lesion presenting T₂-FLAIR mismatch exhibited extremely long T₁- and T₂-relaxation time while T₂-FLAIR matched lesions showed low to moderate values. On the other hand, IDH-wildtype tumors presented noticeably short T₁- and T₂-relaxation time. These different relaxation time characteristics seemed to render T₂-FLAIR mismatch sign of becoming such a unique and specific image feature for IDH-mutant, 1p19q non-codeleted astrocytoma.