Tau Imaging in the 4-Repeat-Tauopathies Progressive Supranuclear Palsy and Corticobasal Syndrome

Abstract

In line with known neuropathological changes, the spatial pattern and magnitude of C-PBB3 tau binding differ between CBS, PSP, and AD, which may be of diagnostic utility. Thus, C-PBB3 offers a promising lead structure for development of ligands for tau imaging, including 4R-tauopathies.