Virus-Like Fe₃O₄@Bi₂S₃ Nanozymes with Resistance-Free Apoptotic Hyperthermia-Augmented Nanozymitic Activity for Enhanced Synergetic Cancer Therapy

Abstract

Nanomaterials with intrinsic peroxidase-like activities are able to catalyze the oxidation of the substrate with the peroxide, which have been widely considered as artificial enzymatic agents in cancer therapy. However, current peroxidase catalytic oxidation treatments generating reactive oxygen species rely highly on hydrogen peroxide and pH, which limit greatly their therapeutic efficiency in the tumor microenvironment. Here, we report a strategy to construct the complex virus-like Fe₃O₄@Bi₂S₃ nanocatalysts (F-BS NCs) by connecting typical peroxidase Fe₃O₄ (MNPs) with a narrow band gap semiconductor Bi₂S₃ (BS) to enhance the enzymatic activity resorting to the limited intratumoral peroxide and efficient external photothermal stimuli. In this formulation, the integrated F-BS NCs induce cancer-cell death through mild photothermal treatment and sequential photothermal-stimulative catalysis of H₂O₂ into highly toxic ^•OH under 808 nm laser, which successfully realize a remarkable synergistic anticancer achievement.