Direct Synthesis of Sulfonylated Spiro[indole-3,3′-pyrrolidines] by Silver-Mediated Sulfonylation of Acrylamides Coupled with Indole Dearomatization

Abstract

A dearomative tandem spiro-cyclization reaction of <i>N</i>-[(1<i>H</i>-indol-3-yl)methyl]methacrylamide derivatives with sulfinate sodium in the presence of AgNO₃ and K₂CO₃ is reported, which produced sulfonylated spiro[indole-3,3'-pyrrolidines] in medium to excellent yields. The characteristics of this transformation contain good functional group tolerance and ease of operation.