Connectomic Underpinnings of Working Memory Deficits in Schizophrenia: Evidence From a replication fMRI study

Abstract

We demonstrate a putative mechanistic link between connectome topology, hub redistribution, and impaired n-back performance in schizophrenia. The task-dependent modulation of the connectome relates to, but remains inefficient in, improving the performance above par in the presence of severe negative symptoms.