A Swelling-Activated Chloride Current in Microglial Cells is Suppressed by Epac and Facilitated by PKA – Impact on Phagocytosis

Abstract

The activation of β-adrenergic receptors in microglial cells triggers a cAMP-Epac-dependent and a cAMP-PKA-dependent cascade which affects phagocytosis via modulation of the swelling-activated Cl- current I_Cl,swell.