Concepedia

Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease‐informed machine‐learning

Nicolai Franzmeier, Nikolaos Koutsouleris, Tammie L.S. Benzinger, Alison Goate, Celeste M. Karch, Anne M. Fagan, Eric McDade, Marco Duering, Martin Dichgans, Johannes Levin,

Alzheimer s & Dementia · 2020 · 70 citations · 39 references

DOIFull text

Open access

Abstract

Our independently validated machine-learning model predicted cognitive decline in sporadic prodromal AD and may substantially reduce sample size needed in clinical trials in AD.

References

39

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman, Chengjie Xiong, Tammie L.S. Benzinger et al. · New England Journal of Medicine · 2012 · 3.7K citations · Full text

Performance evaluation of classification algorithms by k-fold and leave-one-out cross validation

Tzu-Tsung Wong · Pattern Recognition · 2015 · 1.4K citations

, , +14

CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment

Niklas Mattsson · JAMA · 2009 · 1.1K citations

Amyloid deposition, hypometabolism, and longitudinal cognitive decline

Susan Landau, Mark A. Mintun, Abhinay D. Joshi et al. · Annals of Neurology · 2012 · 722 citations · Full text

Alzheimer's disease drug development pipeline: 2018

Jeffrey L. Cummings, Garam Lee, Aaron Ritter et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 2018 · 705 citations · Full text