The Journal of Antibiotics · 2001 · 27 citations · 0 references
Life SciencesBiochemistryMicrobiologyAquatic MicrobiologyDrug DiscoveryMicrobial EcologyAquatic Microbial EcologyFungal Natural Product BiosynthesisFungal Secondary MetabolitesMarine Natural Product BiosynthesisAntimicrobial Marine CompoundsLipopeptide AntibioticsMarine Microbial AntibioticsMarine Microbial Natural ProductsMarine-derived Antimicrobial Compounds
The structures of new cyclic decadepsipeptides, clavariopsins A and B, were determined to be cyclo[-(R)-2-hydroxyisovaleryl-L-pipecoyl-L-MeVal-L-Val-L-MeAsp-L-MeIle-L-MeIle-Gly L-MeVal-L-Tyr(OMe)-] and cyclo[-(R)-2-hydroxyisovaleryl-L-pipecolyl-L-Val-L-Val-L-MeAsp-L-Melle-L-MeIle-Gly-L-MeVal-L-Tyr(OMe)-], respectively, by spectroscopic analyses, especially using 2D NMR techniques. The absolute stereochemistry was elucidated by the advanced Marfey's method and chiral HPLC analysis.