ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Abstract

ZNF143, as a tumor oncogene, promoted the proliferation of GC cells both <i>in vitro</i> and <i>in vivo</i>, indicating that ZNF143 might function as a novel target for GC therapy.<i>in vitro</i>. The downregulation of ZNF143 facilitated cell apoptosis. ZNF143 decreased the ROS level in GC cells, resulting in the reduction of cell apoptosis. Transfection with p53 reversed the antiapoptotic effect of ZNF143, while pifithrin-<i>in vivo</i> was examined using tumor xenograft assay.