Concepedia

A mutation in p62 protein (p. R321C), associated to Paget's disease of bone, causes a blockade of autophagy and an activation of NF-kB pathway

Ricardo Usategui‐Martín, Nerea Gestoso-Uzal, Ismael Calero‐Paniagua, José M. de Pereda, Javier del Pino‐Montes, Rogelio González‐Sarmiento

Bone · 2020 · 19 citations · 18 references

DOI

Concepts

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18

Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 7K citations · Full text

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe et al. · Autophagy · 2016 · 6K citations · Full text

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

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Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

Yoshinobu Ichimura, Taichi Kumanomidou, Yu‐shin Sou et al. · Journal of Biological Chemistry · 2008 · 794 citations · Full text

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<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Faisal Fecto · Archives of Neurology · 2011 · 643 citations

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