Photodisinfection Effects of Silver Sulfadiazine Nanoliposomes Doped-Curcumin on <i>Acinetobacter Baumannii</i> : A Mouse Model

Abstract

<b>Aim:</b> To evaluate the antimicrobial effects of photoexcited silver sulfadiazine nanoliposomes (AgSD-NLs) doped by curcumin (AgSD-NLs@Cur) on <i>Acinetobacter baumannii</i>. <b>Materials & methods:</b> Following characterization, the cytotoxic and hemolytic activities of AgSD-NLs@Cur were evaluated. The antimicrobial activities of AgSD-NLs@Cur-mediated antimicrobial photodynamic therapy (aPDT) were determined. Histopathological examination of the burn wound sites of infected mice treated with photoexcited AgSD-NLs@Cur was assessed. <b>Results:</b> No significant cytotoxic and hemolytic activities were observed. There was a decrease in the <i>Acinetobacter baumannii</i> count in planktonic and biofilm forms and the gene expression level using AgSD-NLs@Cur-aPDT (p < 0.05). Histopathological analysis indicated the epidermis developed markedly and the bacterial load decreased significantly after aPDT. <b>Conclusion:</b> Photoexcited AgSD-NLs@Cur has an antimicrobial potential against <i>A. baumannii</i>.