Freestanding Hyaluronic Acid/Silk-Based Self-healing Coating toward Tissue Repair with Antibacterial Surface

Abstract

Developing coatings with multifunctional and biocompatible properties to enhance tissue wound regeneration is preferably applied clinically. Consequently, the freestanding and self-healing coatings were formed with the employment of the layer-by-layer (LbL) self-assembly. The coatings comprise beta-cyclodextrin-modified silk fibroin (SCD) and adamantane-modified hyaluronic acid (HAD) on the basis of the interactions between the host and the guest. The self-healing and freestanding capabilities allow the coatings to easily and repeatedly repair external mechanical damage and could be pulled off substrate. More importantly, the coatings have admirable antibacterial activity and biocompatibility. Moreover, the proliferation of cells and the myelination of Schwann cells are enhanced. Thus, we believe that the multifunctional coatings will have great potential in tissue engineering, especially for nerve regeneration.