The first zwitterionic cocrystal of indomethacin with amino acid showing optimized physicochemical properties as well as accelerated absorption and slowed elimination <i>in vivo</i>

Abstract

The first zwitterionic cocrystal of indomethacin (INC) with proline (PL) with optimized <italic>in vitro</italic>/<italic>in vivo</italic> properties was prepared and characterized.