Pharmacodynamic Correlates of Linezolid Activity and Toxicity in Murine Models of Tuberculosis

Abstract

Although T>MIC was the most consistent correlate of efficacy, AUC/MIC was equally predictive when bacterial multiplication was constrained by host immunity or pretomanid. In effective combination regimens, administering the same total LZD dose less frequently may be equally effective and cause less Cmin-dependent toxicity.