Synthesis of co-polymeric network of carbopol-g-methacrylic acid nanogels drug carrier system for gastro-protective delivery of ketoprofen and its evaluation

Abstract

Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.