Computational Model of Cell Deformation Under Fluid Flow Based Rolling

Abstract

Physiological environment in which cells live exert continuous mechanical stimuli resulting in deformability which is involved in different cell functions. In this context, we conducted a quantitative study on a single cell presenting a mechanical model for cell adhesion with detachment. Specifically, we will examine the neo-Hookean deformation and the fluid-flow responsible of cell rolling in bloodstream. Finite element analysis was used for the modeling of blood cells attached on the vessel wall, in order to detect the inhomogeneities of deformation (e.g. areas at different concentration and different strain). Therefore, the developed model can be used for simulating cell interaction in an endothelial vessel or in different simply and complex scenario.