Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Abstract

Three new polyketides, ketidocillinones A-C (<b>1</b>-<b>3</b>), were discovered from the extract of an Antarctica sponge-derived fungus <i>Penicillium</i> sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound <b>3</b> was established by using ECD calculation. Compounds <b>1</b>-<b>3</b> can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (<b>2</b> and <b>3</b>) exhibited potent antibacterial activity against <i>Pseudomonas aeurigenosa</i>, <i>Mycobacterium phlei,</i> and MRCNS (methicillin-resistant coagulase-negative <i>staphylococci</i>) with MIC values ranging from 1.56 to 25.00 µg/mL.