Blockade of BDNF signalling attenuates chronic visceral hypersensitivity in an IBS‐like rat model

Abstract

ANA-12 attenuates visceral hypersensitivity via BDNF-TrkB-PKMζ signalling and reduces synaptic activity through AMPARs in NMS rats. This knowledge suggests that ANA-12 could represent an interesting novel therapeutic medicine for chronic visceral hypersensitivity.