N‐Heterocyclic Carbene‐Catalyzed Activation of Ynals for the Construction of Functional Pyridines

Abstract

Abstract N‐heterocyclic carbene‐catalyzed activation of ynals for rapid synthesis of pyridine derivatives with important utilities has been reported. This successful strategy using NHC‐bound alkynyl acyl azolium as the key intermediate further improved the application of N ‐Ts 2‐aminoacrylate as a nucleophile. Importantly, this work introduces an ester substituent to pyridines that could be easily transformed to other functional groups.