NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma

Abstract

5FU followed by p50-IMC slows the growth of murine prostate and pancreatic carcinoma and depends on CD8⁺ T cell activation. Deletion of p50 in patient-derived marrow CD34⁺ cells and subsequent production of IMC for adoptive transfer may contribute to the therapy of these and additional cancers.